bucket foundation — inverse omegabucket.foundation
§ Research · tools

run real instruments.

Twenty tools, each running real logic on your input — protein stability, ADMET screening, trajectory mining, ephys, and cryo-EM triage; five literature/agent tools over the live OpenAlex index and a real awarded-grant corpus (PaperRadar, GrantDraft, MethodsMatcher, ReviewGuard, QuantumBioRAG); a DNA/RNA cluster (RNAStructure folding via ViennaRNA, gRNA-Optimizer, RNA-FM-Embeds); a neuroscience cluster (HH-FitML membrane fits, SpikeFeatures detection); and a gap-research cluster (ProtocolGPT methods structuring, ToxinChannelFinder, CitationGraph). Run one, read the result, and publish it to canon as a citeable, paid-once artifact.

always-on · Hetzner CPU, 24/7founder GPU · offline when the laptop is closedfund always-on hosting →
LabBrain
CPU · live
founder GPU

Grounded literature assistant over a research PI's corpus. Resolves the lab on OpenAlex, ingests open-access full text, hybrid dense+BM25 retrieval, answers with citations.

open tool →
StabilityDesigner
CPU · live
always-on

Predict ΔΔG of point mutations; deep-mutational scan a position.

open tool →
ProteinScout
CPU · live
always-on

ML structural / disorder / feature analysis from a sequence or UniProt accession.

open tool →
ScreenServer
CPU · live
always-on

13 ADMET models over a SMILES library; ranked drug-likeness report.

open tool →
TrajMine
GPU · demo
founder GPU

Mine molecular-dynamics trajectories for conformational structure (demo trajectory until GPU compute lands).

open tool · demo →
PatchSeqML
CPU · live
always-on

ML over patch-clamp electrophysiology recordings; cell-type signatures.

open tool →
CryoTriage
GPU · demo
founder GPU

Triage cryo-EM micrographs for quality (synthetic session until GPU compute lands).

open tool · demo →
PaperRadar
RAG · live
always-on

Personalized recent-paper feed. Queries the live OpenAlex index for your topics, ranks by relevance + recency + citation velocity, and explains why each matters to you.

open tool →
GrantDraft
RAG · live
always-on

Funder finder + specific-aims drafter, grounded in real awarded NSF grants (research-atlas corpus). Shows who funds your area and drafts aims anchored to actual awards.

open tool →
MethodsMatcher
RAG · live
always-on

Which method answers your question? Mines the recurring methods in the live OpenAlex literature and points you to the Bucket tool that runs it.

open tool →
ReviewGuard
RAG · live
always-on

Cross-paper consistency check. State a claim; ReviewGuard sorts the OpenAlex literature into supporting vs contradicting, quoting the deciding sentence.

open tool →
QuantumBioRAG
RAG · live
always-on

Evidence, not hype. State a quantum-biology claim; QuantumBioRAG scores how strongly the live OpenAlex literature supports it — weighting each paper by overlap, citations, and recency — with a consensus score and the deciding sentences.

open tool →
RNAStructure
DNA · live
always-on

RNA secondary-structure prediction via ViennaRNA: MFE dot-bracket structure, free energy, partition-function base-pair probabilities, and a readable helix/loop summary. Fully real thermodynamics.

open tool →
gRNA-Optimizer
DNA · live
always-on

CRISPR SpCas9 guide design: PAM scan on both strands, transparent on-target efficiency scoring, and a local seed-region off-target risk flag. Ranked, defensible guide table.

open tool →
RNA-FM-Embeds
DNA · live
always-on

RNA → ML embedding. Real RNA-FM language-model representation when its weights are installed; otherwise an honest, reproducible k-mer + structural-feature embedding (mode reported).

open tool →
HH-FitML
NEURO · live
always-on

Fit passive-membrane (RC) parameters — R, C, τ, V₀ — to a current-clamp trace via scipy least-squares, with fit quality (R²/RMSE). A demo trace with known params verifies recovery.

open tool →
SpikeFeatures
NEURO · live
always-on

Detect spikes in a voltage trace (MAD-robust threshold + refractory + alignment) and extract real waveform features — amplitude, width, half-width, firing rate, ISI stats. Demo train has a known spike count.

open tool →
ProtocolGPT
GAP · live
always-on

Methods prose → a structured, runnable protocol. Deterministic rule extraction over a methods knowledge base: ordered steps with timings/temps/volumes, a reagent table, and safety flags. No network, no GPU.

open tool →
ToxinChannelFinder
GAP · live
always-on

Map a toxin/peptide (name or sequence) to its likely ion-channel targets. Fuses a curated venom-peptide pharmacology KB with live OpenAlex co-occurrence; sequences classified by cysteine framework. Ranked targets, honest confidence, cited exemplars.

open tool →
CitationGraph
GAP · live
always-on

Build a paper's local citation neighborhood from the live OpenAlex graph (DOI / OpenAlex ID / title). Surfaces the key related works and ranks them by degree centrality — the most-connected neighbors first.

open tool →