Corpus evidence — top 10 passages

Most-relevant passages from the entire indexed corpus (67,286 paragraph chunks across YouTube transcripts, PubMed, arXiv, archive.org, Stanford Encyclopedia of Philosophy, OpenAlex, and more) ranked by semantic similarity (bge-small-en-v1.5).

1. 01 · _intake0.793

   - [`001-on-board-with-what-i-ve-heard-you-say-about-the-fact-that-th`](dopamine/001-on-board-with-what-i-ve-heard-you-say-about-the-fact-that-th.md) — score=6 `00:02:28.620` — on board with what I've heard you say about the fact that the way that all the base pairs in DNA and the way that amino - [`002-decreases-somewhat-that-produces-a-dopamine-kick-and-that-s-`](dopamine/002-decreases-somewhat-that-produces-a-dopamine-kick-and-that-s-.md) — score=5 `00:47:56.640` — decreases somewhat, that produces a dopamine kick. And that's a signal of reduced entropy in relationship. And it seems - [`003-…

   _intake/claims-allbranch/curated-low/INDEX.md

2. 02 · _intake0.772

   So the real question becomes: what are the causes of low dopamine?” Is it bad food, bad ideas? In [Brain Gut 11](https://jackkruse.com/brain-gut-11-is-technology-your-achilles-heel/) we examined the cause of low dopamine levels and how they relate to low AM cortisol levels. Here we even talked about how to treat it with a drug like Cycloset. Is there any other way to raise our dopamine levels naturally to avoid procrastination?

   _intake/kruse-blog-corpus/articles/the-dopamine-rx-good-choices-or-bad.md

3. 03 · _intake0.770

   Yes is the short answer, and that is why I took a jet plane plane up past the 63 parallel and climbed into a deep dark cold hole hole to see if I could overcome procrastination and increase my decision making acutely without using drugs like cycloset. Anyone who reads this blog knows that leptin sensitivity is directly tied to dopamine levels on a very basic level. ***If you are LR you, by definition, have an altered dopamine level in your brain, pure and simple. It also means at the core, your mitochondria just flat don’t work well when dopamine levels are poor.***

   _intake/kruse-blog-corpus/articles/the-dopamine-rx-good-choices-or-bad.md

4. 04 · _intake0.768

   > always there, but you know what the key thing is? We don't see them because we're obedient idiots because we're addicted to modern things that reduce our dopamine level. My job is to make

   _intake/claims-allbranch/curated-low/dopamine/005-always-there-but-you-know-what-the-key-thing-is.md

5. 05 · yt0.763

   And the idea that there's two sides of that, and actually, this is a good idea to introduce this term of hormesis, which you and I were talking about offline, the idea that you have this addiction circuit where you get a reward, but then you drop to a baseline that's below the original baseline, and then it's a downward spiral, versus hormesis, which is more like exercise. Can you explain hormesis? - [Daniel] Yeah. And I just wanna say, because you have an educated audience, we're simplifying everything for model purpose and speed purpose. Obviously, it's not just dopamine, right? You can have…

   yt/_7aIgHoydP8-saving-civilization-healthcare-tech-democracy-w-daniel-schma/transcript.txt

6. 06 · _intake0.760

   BTW, doc, can you start writing some blog posts about mental disorders? It'd be very interesting to see your take on the subject of mental disorders from a biochemical perspective!

   _intake/kruse-blog-corpus/articles/reality-19-mitochondriac-basics-sun.md

7. 07 · _intake0.759

   **Critics find faults, but leaders find remedies.** I realized in an instant, that my life was being ruined my behavior; It affected my sleep, my persona, and my health. Did I fall back to revert to mean? I was already living in the face of abject failure? No, I did not. I was sick and tired of being sick and tired. I was already at the point of no return. So what did I do? I read some books to gain a new perspective, of whatI might be missing. I decided to try to use other’s perspectives about failure and change drive “thought experiments” in my brain to increase my dopamine levels. This ulti…

   _intake/kruse-blog-corpus/articles/christmas-gift-2014-re-think-life.md

8. 08 · _intake0.758

   The core of Pic’s problem was life long choices and procrastination that subjugated his health. He has kids and friends and family who have also fallen prey to this insidous brain disease. Poor choices are all tied to a problem with dopamine signaling. In fact most of us faced with change of any kind have to deal with these type of decisions. Procrastination is a huge hurdle for any change we face in life.

   _intake/kruse-blog-corpus/articles/the-dopamine-rx-good-choices-or-bad.md

9. 09 · _intake0.753

   This is the core question one needs to examine for all change. People fall into dogma because they lose their ability to be curious as dopamine falls in the brain. People do this because they learn this behavior from their peers and their parents. They learn it from the people they respect. I realized why I was mad at Pic when I thought about it. I respected him, but I was madder than hell because I realized he laid in that bed because he never listened to my advice and led a life he learned over 80 some odd years. I could not accept his choices so I got angry at him. I should not have gotten …

   _intake/kruse-blog-corpus/articles/the-dopamine-rx-good-choices-or-bad.md

10. 10 · _intake0.749

    This causes a de-coherence in cells. This is how a physicist would explain it. A regular person would describe it as a shorting out of the system. A blown fuse, so to speak. It simulates what a “brown out” may look like in living thing. This is why people with Parkinson’s disease get an expressionless face, seem to lose their emotion, and why their muscle motions seem to slow down so much. Thinking is slowed and cognitive haze develops. These are the terms people use to describe a low dopamine state. Low dopamine states affect the global control of the organism and it also impairs the ability …

    _intake/kruse-blog-corpus/articles/reality-12-dopamine-blinds-us-from-natures-fractal-fabric.md